8,924 research outputs found
Sound-suppressing structure with thermal relief
Sound-suppressing structure comprising stacked acoustic panels wherein the inner high frequency panel is mounted for thermal expansion with respect to the outer low frequency panel is discussed. Slip joints eliminate the potential for thermal stresses, and a thermal expansion gap between the panels provides for additional relative thermal growth while reducing heat convection into the low frequency panel
Study of EVA operations associated with satellite services
Extravehicular mobility unit (EMU) factors associated with satellite servicing activities are identified and the EMU improvements necessary to enhance satellite servicing operations are outlined. Areas of EMU capabilities, equipment and structural interfaces, time lines, EMU modifications for satellite servicing, environmental hazards, and crew training are vital to manned Eva/satellite services and as such are detailed. Evaluation of EMU capabilities indicates that the EMU can be used in performing near term, basic satellite servicing tasks; however, satellite servicing is greatly enhanced by incorporating key modifications into the EMU. The servicing missions involved in contamination sensitive payload repair are illustrated. EVA procedures and equipment can be standardized, reducing both crew training time and in orbit operations time. By standardizing and coordinating procedures, mission cumulative time lines fall well within the EMU capability
Energy efficient engine: Flight propulsion system preliminary analysis and design
The characteristics of an advanced flight propulsion system (FPS), suitable for introduction in the late 1980's to early 1990's, was more fully defined. It was determined that all goals for efficiency, environmental considerations, and economics could be met or exceeded with the possible exception of NOx emission. In evaluating the FPS, all aspects were considered including component design, performance, weight, initial cost, maintenance cost, engine system integration (including nacelle), and aircraft integration considerations. The current FPS installed specific fuel consumption was reduced 14.2% from that of the CF6-50C reference engine. When integrated into an advanced, subsonic, study transport, the FPS produced a fuel burn savings of 15 to 23% and a direct operating cost reduction of 5 to 12% depending on the mission and study aircraft characteristics relative to the reference engine
Distinct Types of Fibrocyte Can Differentiate from Mononuclear Cells in the Presence and Absence of Serum
Background: Ageing, immunity and stresstolerance are inherent characteristics of all organisms. In animals, these traits are regulated, at least in part, by forkhead transcription factors in response to upstream signals from the Insulin/Insulin–like growth factor signalling (IIS) pathway. In the nematode Caenorhabditis elegans, these phenotypes are molecularly linked such that activation of the forkhead transcription factor DAF-16 both extends lifespan and simultaneously increases immunity and stress resistance. It is known that lifespan varies significantly among the Caenorhabditis species but, although DAF-16 signalling is highly conserved, it is unclear whether this phenotypic linkage occurs in other species. Here we investigate this phenotypic covariance by comparing longevity, stress resistance and immunity in four Caenorhabditis species.
Methodology/Principal Findings: We show using phenotypic analysis of DAF-16 influenced phenotypes that among four closely related Caenorhabditis nematodes, the gonochoristic species (Caenorhabditis remanei and Caenorhabditis brenneri) have diverged significantly with a longer lifespan, improved stress resistance and higher immunity than the hermaphroditic species (C. elegans and Caenorhabditis briggsae). Interestingly, we also observe significant differences in expression levels between the daf-16 homologues in these species using Real-Time PCR, which positively correlate with the observed phenotypes. Finally, we provide additional evidence in support of a role for DAF-16 in regulating phenotypic coupling by using a combination of wildtype isolates, constitutively active daf-16 mutants and bioinformatic analysis.
Conclusions: The gonochoristic species display a significantly longer lifespan (p<0.0001) and more robust immune and stress response (p<0.0001, thermal stress; p<0.01, heavy metal stress; p<0.0001, pathogenic stress) than the hermaphroditic species. Our data suggests that divergence in DAF-16 mediated phenotypes may underlie many of the differences observed between these four species of Caenorhabditis nematodes. These findings are further supported by the correlative higher daf-16 expression levels among the gonochoristic species and significantly higher lifespan, immunity and stress tolerance in the constitutively active daf-16 hermaphroditic mutants
The SED Machine: a robotic spectrograph for fast transient classification
Current time domain facilities are finding several hundreds of transient
astronomical events a year. The discovery rate is expected to increase in the
future as soon as new surveys such as the Zwicky Transient Facility (ZTF) and
the Large Synoptic Sky Survey (LSST) come on line. At the present time, the
rate at which transients are classified is approximately one order or magnitude
lower than the discovery rate, leading to an increasing "follow-up drought".
Existing telescopes with moderate aperture can help address this deficit when
equipped with spectrographs optimized for spectral classification. Here, we
provide an overview of the design, operations and first results of the Spectral
Energy Distribution Machine (SEDM), operating on the Palomar 60-inch telescope
(P60). The instrument is optimized for classification and high observing
efficiency. It combines a low-resolution (R100) integral field unit (IFU)
spectrograph with "Rainbow Camera" (RC), a multi-band field acquisition camera
which also serves as multi-band (ugri) photometer. The SEDM was commissioned
during the operation of the intermediate Palomar Transient Factory (iPTF) and
has already proved lived up to its promise. The success of the SEDM
demonstrates the value of spectrographs optimized to spectral classification.
Introduction of similar spectrographs on existing telescopes will help
alleviate the follow-up drought and thereby accelerate the rate of discoveries.Comment: 21 pages, 20 figure
Development of singularities for the compressible Euler equations with external force in several dimensions
We consider solutions to the Euler equations in the whole space from a
certain class, which can be characterized, in particular, by finiteness of
mass, total energy and momentum. We prove that for a large class of right-hand
sides, including the viscous term, such solutions, no matter how smooth
initially, develop a singularity within a finite time. We find a sufficient
condition for the singularity formation, "the best sufficient condition", in
the sense that one can explicitly construct a global in time smooth solution
for which this condition is not satisfied "arbitrary little". Also compactly
supported perturbation of nontrivial constant state is considered. We
generalize the known theorem by Sideris on initial data resulting in
singularities. Finally, we investigate the influence of frictional damping and
rotation on the singularity formation.Comment: 23 page
Switching to second-line antiretroviral therapy in resource-limited settings: comparison of programmes with and without viral load monitoring.
In high-income countries, viral load is routinely measured to detect failure of antiretroviral therapy (ART) and guide switching to second-line ART. Viral load monitoring is not generally available in resource-limited settings. We examined switching from nonnucleoside reverse transcriptase inhibitor (NNRTI)-based first-line regimens to protease inhibitor-based regimens in Africa, South America and Asia
Solution of the X-ray edge problem for 2D electrons in a magnetic field
The absorption and emission spectra of transitions between a localized level
and a two-dimensional electron gas, subjected to a weak magnetic field, are
calculated analytically. Adopting the Landau level bosonization technique
developed in previous papers, we find an exact expression for the relative
intensities of spectral lines. Their envelope function, governed by the
interaction between the electron gas and the core hole, is reminescent of the
famous Fermi edge singularity, which is recovered in the limit of a vanishing
magnetic field.Comment: 4 pages, 1 figur
Blowup Criterion for the Compressible Flows with Vacuum States
We prove that the maximum norm of the deformation tensor of velocity
gradients controls the possible breakdown of smooth(strong) solutions for the
3-dimensional compressible Navier-Stokes equations, which will happen, for
example, if the initial density is compactly supported \cite{X1}. More
precisely, if a solution of the compressible Navier-Stokes equations is
initially regular and loses its regularity at some later time, then the loss of
regularity implies the growth without bound of the deformation tensor as the
critical time approaches. Our result is the same as Ponce's criterion for
3-dimensional incompressible Euler equations (\cite{po}). Moreover, our method
can be generalized to the full Compressible Navier-Stokes system which improve
the previous results. In addition, initial vacuum states are allowed in our
cases.Comment: 17 page
Weiss Oscillations in Surface Acoustic Wave Propagation
The interaction of a surface acoustic wave (SAW) with a a two-dimensional
electron gas in a periodic electric potential and a classical magnetic field is
considered. We calculate the attenuation of the SAW and its velocity change and
show that these quantities exhibit Weiss oscillations.Comment: 4 pages REVTEX, 2 figures included as eps file
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